Sodium concentration imaging in dermis layer by square-wave open electrical impedance tomography (SW-oEIT) with spatial voltage thresholding (SVT).

In this study, sodium concentration in the dermis layer is imaged by the square wave open electrical impedance tomography (SW-oEIT) with spatial voltage thresholding (SVT). The SW-oEIT with SVT consists of three steps which are (1) voltage measurement, (2) spatial voltage thresholding, and (3) sodium concentration imaging. In the 1st step, the root mean square voltagevis calculated based on the measured voltagevunder the square wave currentIthrough the planar electrodes on the skin domain Ω. In the 2nd step, them-th measured voltagevis converted to a compensated voltagev*based on the voltage electrodes distancedvand threshold distancedΓin order to highlight the region of interest of the dermis layerΩd.In the 3rd step, sodium concentration is imaged by the Gauss-Newton reconstruction method. The SW-oEIT with SVT was applied to multi-layer skin simulation andex-vivoexperiments under various dermis sodium concentrationscin the range of 5-50 mM. As an image evaluation result, the spatial mean conductivity distributionσ*inΩdis successfully determined as increasingcon both simulations and experiments. The relationship between〈σ*〉andcwas evaluated by the determination coefficientR2and the normalized sensitivity〈S〉.The optimizeddΓwith the highest evaluation values ofR2=0.84 and〈S〉=0.83 is under the condition ofdΓ= 2 mm. Based on the signal evaluation, the SW-oEIT with SVT has a 15.32% higher correlation coefficientCCcompared to the conventionaloEIT based on sinewave injection.