Therapeutic Hypothermia in Treating Glioblastoma: A Review.
Ther Hypothermia Temp Manag
; 14(1): 2-9, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-37184912
ABSTRACT
Glioblastoma (GBM) is the most commonly occurring of all malignant central nervous system (CNS) tumors in adults. Considering the low median survival of only â¼15 months and poor prognosis in GBM patients, despite surgical resection with adjuvant radiation and chemotherapy, it is vital to seek brand new and innovative treatment in combination with already existing methods. Hypothermia participates in many metabolic pathways, inflammatory responses, and apoptotic processes, while also promoting the integrity of neurons. Following the successful application of therapeutic hypothermia across a spectrum of disorders such as traumatic CNS injury, cardiac arrest, and epilepsy, several clinical trials have set to evaluate the potency of hypothermia in treating a variety of cancers, including breast and ovaries cancer. In regard to primary neoplasms and more specifically, GBM, hypothermia has recently shown promising results as an auxiliary treatment, reinforcing chemotherapy's efficacy. In this review, we discuss the recent advances in utilizing hypothermia as treatment for GBM and other cancers.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Glioblastoma
/
Hipotermia
/
Hipotermia Inducida
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Ther Hypothermia Temp Manag
Año:
2024
Tipo del documento:
Article
País de afiliación:
Grecia