Loss of LRP1 in Adult Neural Stem Cells Impairs Migration to Ischemic Lesions.
Stem Cells
; 41(6): 570-577, 2023 06 15.
Article
en En
| MEDLINE
| ID: mdl-37186298
ABSTRACT
After ischemia, cells in the brain parenchyma upregulate stromal derived factor 1 (SDF1), driving chemokine receptor CXCR4-mediated migration of adult neural stem cells to the ischemic injury. We discovered a novel regulator of CXCR4 in neural stem cells, low-density lipoprotein receptor related protein 1 (LRP1). We used Nestin-driven knockout of LRP1 and induction of td-tomato in neural stem cells of adult mice. We observed reduced localization of td-tomato positive cells to the lesion, and find disrupted CXCR4-mediated neural stem cell migration in vitro, which is likely driven by LRP1-mediated loss of CXCR4 expression in vivo. Our results suggest that LRP1 is a novel regulator of CXCR4 in neural stem cells. This heretofore unknown interaction between LRP1 and CXCR4 could have significant consequences for multiple aspects of neural stem cell physiology.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quimiocina CXCL12
/
Células-Madre Neurales
Límite:
Animals
Idioma:
En
Revista:
Stem Cells
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos