Study on the Interaction between Silibinin and Neuraminidase.
Curr Pharm Des
; 29(16): 1266-1273, 2023.
Article
en En
| MEDLINE
| ID: mdl-37190805
ABSTRACT
BACKGROUND:
Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity.OBJECTIVE:
This study aims to explore the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase.METHODS:
In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry, Uv-vis spectroscopy, and circular dichroism analysis were used.RESULTS:
Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase.CONCLUSION:
Silibinin can interact with neuraminidase and inhibit its activity.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Virus de la Influenza A
/
Silibina
/
Neuraminidasa
Límite:
Animals
Idioma:
En
Revista:
Curr Pharm Des
Asunto de la revista:
FARMACIA
Año:
2023
Tipo del documento:
Article
Pais de publicación:
AE
/
EMIRADOS ÁRABES UNIDOS
/
EMIRATOS ARABES UNIDOS
/
UNITED ARAB EMIRATES