The dynamics of Mycobacterium tuberculosis phagosome and the fate of infection.
Cell Signal
; 108: 110715, 2023 08.
Article
en En
| MEDLINE
| ID: mdl-37192679
ABSTRACT
Phagosomes are vesicles produced by phagocytosis of phagocytes, which are crucial in immunity against Mycobacterium tuberculosis (Mtb) infection. After the phagocyte ingests the pathogen, it activates the phagosomes to recruit a series of components and process proteins, to phagocytose, degrade and kill Mtb. Meanwhile, Mtb can resist acid and oxidative stress, block phagosome maturation, and manipulate host immune response. The interaction between Mtb and phagocytes leads to the outcome of infection. The dynamic of this process can affect the cell fate. This article mainly reviews the development and maturation of phagosomes, as well as the dynamics and modifications of Mtb effectors and phagosomes components, and new diagnostic and therapeutic markers involved in phagosomes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mycobacterium tuberculosis
Idioma:
En
Revista:
Cell Signal
Año:
2023
Tipo del documento:
Article
País de afiliación:
China