Extracellular vesicles: A new communication paradigm of complement in neurological diseases.
Brain Res Bull
; 199: 110667, 2023 07.
Article
en En
| MEDLINE
| ID: mdl-37192717
ABSTRACT
The complement system is crucial to the innate immune system. It has the function of destroying pathogens by activating the classical, alternative, and lectin pathways. The complement system is important in nervous system diseases such as cerebrovascular and neurodegenerative diseases. Activation of the complement system involves a series of intercellular signaling and cascade reactions. However, research on the source and transport mechanisms of the complement system in neurological diseases is still in its infancy. Studies have increasingly found that extracellular vesicles (EVs), a classic intercellular communication paradigm, may play a role in complement signaling disorders. Here, we systematically review the EV-mediated activation of complement pathways in different neurological diseases. We also discuss the prospect of EVs as future immunotherapy targets.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Neurodegenerativas
/
Vesículas Extracelulares
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Brain Res Bull
Año:
2023
Tipo del documento:
Article
País de afiliación:
China