Exosomes as cutting-edge therapeutics in various biomedical applications: An update on engineering, delivery, and preclinical studies.
Biochimie
; 213: 139-167, 2023 Oct.
Article
en En
| MEDLINE
| ID: mdl-37207937
ABSTRACT
Exosomes are cell-derived nanovesicles, circulating in different body fluids, and acting as an intercellular mechanism. They can be purified from culture media of different cell types and carry an enriched content of various protein and nucleic acid molecules originating from their parental cells. It was indicated that the exosomal cargo can mediate immune responses via many signaling pathways. Over recent years, the therapeutic effects of various exosome types were broadly investigated in many preclinical studies. Herein, we present an update on recent preclinical studies on exosomes as therapeutic and/or delivery agents for various applications. The exosome origin, structural modifications, natural or loaded active ingredients, size, and research outcomes were summarized for various diseases. Overall, the present article provides an overview of the latest exosome research interests and developments to clear the way for the clinical study design and application.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Exosomas
Idioma:
En
Revista:
Biochimie
Año:
2023
Tipo del documento:
Article
País de afiliación:
Irán