PCSK6 mediates Th1 differentiation and promotes chronic colitis progression and mucosal barrier injury via STAT1.

Mei, Xiaoping; Zhou, Hongkun; Song, Zhengwei; Yang, Xiaodan; Liu, Xiaorong; Fei, Jianguo; Shen, Yiyu; Wang, Xiaoguang

Mei, Xiaoping; Zhou, Hongkun; Song, Zhengwei; Yang, Xiaodan; Liu, Xiaorong; Fei, Jianguo; Shen, Yiyu; Wang, Xiaoguang.

Afiliación

Mei X; Department of Surgery, Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, People’s Republic of China.
Zhou H; Department of Surgery, Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, People’s Republic of China.
Song Z; Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, People’s Republic of China.
Yang X; Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, People’s Republic of China.
Liu X; Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, People’s Republic of China.
Fei J; Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, People’s Republic of China.
Shen Y; Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, People’s Republic of China.
Wang X; Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, People’s Republic of China.

Aging (Albany NY) ; 15(10): 4363-4373, 2023 05 20.

Article en En | MEDLINE | ID: mdl-37211384

Asunto(s)

Colitis; Enfermedades Inflamatorias del Intestino; Ratones; Animales; Colitis/inducido químicamente; Colitis/metabolismo; Macrófagos/metabolismo; Membrana Mucosa/metabolismo; Diferenciación Celular; Ratones Endogámicos C57BL; Factor de Transcripción STAT1/genética; Factor de Transcripción STAT1/metabolismo

Palabras clave

M1 macrophages; PCSK6; chronic colitis; helper T cells; inflammation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis Límite: Animals Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos

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