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Immune Responses After Vaccination With Primary 2-Dose ChAdOx1 Plus a Booster of BNT162b2 or Vaccination With Primary 2-Dose BNT162b2 Plus a Booster of BNT162b2 and the Occurrence of Omicron Breakthrough Infection.
Choi, Seong-Ho; Park, Ji Young; Kweon, Oh Joo; Park, Joung Ha; Kim, Min-Chul; Lim, Yaeji; Chung, Jin-Won.
Afiliación
  • Choi SH; Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea.
  • Park JY; Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.
  • Kweon OJ; Department of Laboratory Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea.
  • Park JH; Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea.
  • Kim MC; Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea.
  • Lim Y; Department of Applied Statistics, Chung-Ang University, Seoul, Korea.
  • Chung JW; Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea. drjwchung@cau.ac.kr.
J Korean Med Sci ; 38(20): e155, 2023 May 22.
Article en En | MEDLINE | ID: mdl-37218354
ABSTRACT

BACKGROUND:

Before the omicron era, health care workers were usually vaccinated with either the primary 2-dose ChAdOx1 nCoV-19 (Oxford-AstraZeneca) series plus a booster dose of BNT162b2 (Pfizer-BioNTech) (CCB group) or the primary 2-dose BNT162b2 series plus a booster dose of BNT162b2 (BBB group) in Korea.

METHODS:

The two groups were compared using quantification of the surrogate virus neutralization test for wild type severe acute respiratory syndrome coronavirus 2 (SVNT-WT), the omicron variant (SVNT-O), spike-specific IgG, and interferon-gamma (IFN-γ), as well as the omicron breakthrough infection cases.

RESULTS:

There were 113 participants enrolled in the CCB group and 51 enrolled in the BBB group. Before and after booster vaccination, the median SVNT-WT and SVNT-O values were lower in the CCB (SVNT-WT [before-after] 72.02-97.61%, SVNT-O 15.18-42.29%) group than in the BBB group (SVNT-WT 89.19-98.11%, SVNT-O 23.58-68.56%; all P < 0.001). Although the median IgG concentrations were different between the CCB and BBB groups after the primary series (2.677 vs. 4.700 AU/mL, respectively, P < 0.001), they were not different between the two groups after the booster vaccination (7.246 vs. 7.979 AU/mL, respectively, P = 0.108). In addition, the median IFN-γ concentration was higher in the BBB group than in the CCB group (550.5 and 387.5 mIU/mL, respectively, P = 0.014). There was also a difference in the cumulative incidence curves over time (CCB group 50.0% vs. BBB group 41.8%; P = 0.045), indicating that breakthrough infection occurred faster in the CCB group.

CONCLUSION:

The cellular and humoral immune responses were low in the CCB group so that the breakthrough infection occurred faster in the CCB group than in the BBB group.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Vacuna BNT162 Límite: Humans Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Vacuna BNT162 Límite: Humans Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article