Ant venoms contain vertebrate-selective pain-causing sodium channel toxins.
Nat Commun
; 14(1): 2977, 2023 05 23.
Article
en En
| MEDLINE
| ID: mdl-37221205
ABSTRACT
Stings of certain ant species (Hymenoptera Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms are venom peptides that modulate the activity of voltage-gated sodium (NaV) channels, reducing their voltage threshold for activation and inhibiting channel inactivation. These peptide toxins are likely vertebrate-selective, consistent with a primarily defensive function. They emerged early in the Formicidae lineage and may have been a pivotal factor in the expansion of ants.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormigas
/
Toxinas Biológicas
/
Venenos de Hormiga
Límite:
Animals
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Australia