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Ant venoms contain vertebrate-selective pain-causing sodium channel toxins.
Robinson, Samuel D; Deuis, Jennifer R; Touchard, Axel; Keramidas, Angelo; Mueller, Alexander; Schroeder, Christina I; Barassé, Valentine; Walker, Andrew A; Brinkwirth, Nina; Jami, Sina; Bonnafé, Elsa; Treilhou, Michel; Undheim, Eivind A B; Schmidt, Justin O; King, Glenn F; Vetter, Irina.
Afiliación
  • Robinson SD; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia. sam.robinson@uq.edu.au.
  • Deuis JR; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • Touchard A; CNRS, UMR Ecologie des forêts de Guyane (EcoFoG), Campus Agronomique; BP 316, 97379, Kourou, Cedex, France.
  • Keramidas A; Equipe BTSB-EA 7417, Université de Toulouse, Institut National Universitaire Jean-François Champollion; Place de Verdun, 81012, Albi, France.
  • Mueller A; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • Schroeder CI; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • Barassé V; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • Walker AA; Genentech, 1 DNA Way, South San Francisco, 94080, CA, USA.
  • Brinkwirth N; Equipe BTSB-EA 7417, Université de Toulouse, Institut National Universitaire Jean-François Champollion; Place de Verdun, 81012, Albi, France.
  • Jami S; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • Bonnafé E; Nanion Technologies, Munich, 80339, Germany.
  • Treilhou M; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • Undheim EAB; Equipe BTSB-EA 7417, Université de Toulouse, Institut National Universitaire Jean-François Champollion; Place de Verdun, 81012, Albi, France.
  • Schmidt JO; Equipe BTSB-EA 7417, Université de Toulouse, Institut National Universitaire Jean-François Champollion; Place de Verdun, 81012, Albi, France.
  • King GF; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • Vetter I; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, The University of Oslo, Oslo, Norway.
Nat Commun ; 14(1): 2977, 2023 05 23.
Article en En | MEDLINE | ID: mdl-37221205
ABSTRACT
Stings of certain ant species (Hymenoptera Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms are venom peptides that modulate the activity of voltage-gated sodium (NaV) channels, reducing their voltage threshold for activation and inhibiting channel inactivation. These peptide toxins are likely vertebrate-selective, consistent with a primarily defensive function. They emerged early in the Formicidae lineage and may have been a pivotal factor in the expansion of ants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormigas / Toxinas Biológicas / Venenos de Hormiga Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormigas / Toxinas Biológicas / Venenos de Hormiga Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Australia