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Colorectal cancer: Review of signaling pathways and associated therapeutic strategies.
Leiphrakpam, Premila D; Rajappa, Senthil J; Krishnan, Mridula; Batra, Rishi; Murthy, Shilpa S; Are, Chandrakanth.
Afiliación
  • Leiphrakpam PD; Graduate Medical Education, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Rajappa SJ; Department of Surgery, Division of Surgical Oncology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Krishnan M; Medical Oncology, Basavatarakam Indo-American Cancer Hospital, Hyderabad, Telangana, India.
  • Batra R; Department of Internal Medicine, Division of Oncology & Hematology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Murthy SS; Department of Surgery, Division of General Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Are C; Global Cancer Disparities Initiative, Division of Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
J Surg Oncol ; 127(8): 1277-1295, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37222698
Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Neoplasias del Colon Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Surg Oncol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Neoplasias del Colon Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Surg Oncol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos