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The Roles of the Amyloid Beta Monomers in Physiological and Pathological Conditions.
Schreiner, Thomas Gabriel; Schreiner, Oliver Daniel; Adam, Maricel; Popescu, Bogdan Ovidiu.
Afiliación
  • Schreiner TG; Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iași, Romania.
  • Schreiner OD; Faculty of Electrical Engineering and Information Technology, Gheorghe Asachi Technical University of Iasi, 21-23 Professor Dimitrie Mangeron Blvd., 700050 Iasi, Romania.
  • Adam M; Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania.
  • Popescu BO; Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iași, Romania.
Biomedicines ; 11(5)2023 May 10.
Article en En | MEDLINE | ID: mdl-37239082
ABSTRACT
Amyloid beta peptide is an important biomarker in Alzheimer's disease, with the amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of dementia. Despite numerous studies, the etiology of Alzheimer's disease remains incompletely known, as the pathological accumulation of amyloid beta aggregates cannot fully explain the complex clinical picture of the disease. Or, for the development of effective therapies, it is mandatory to understand the roles of amyloid beta at the brain level, from its initial monomeric stage prior to aggregation in the form of senile plaques. In this sense, this review aims to bring new, clinically relevant data on a subject intensely debated in the literature in the last years. In the first part, the amyloidogenic cascade is reviewed and the possible subtypes of amyloid beta are differentiated. In the second part, the roles played by the amyloid beta monomers in physiological and pathological (neurodegenerative) conditions are illustrated based on the most relevant and recent studies published on this topic. Finally, considering the importance of amyloid beta monomers in the pathophysiology of Alzheimer's disease, new research directions with diagnostic and therapeutic impacts are suggested.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Rumanía

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Rumanía