HIV and inflammatory markers are associated with persistent COVID-19 symptoms.
Immun Inflamm Dis
; 11(5): e859, 2023 05.
Article
en En
| MEDLINE
| ID: mdl-37249281
ABSTRACT
BACKGROUND:
A proportion of COVID19 survivors may present with long-COVID, which is persistent symptoms lasting four or more weeks post SARS-CoV-2 infection. These symptoms may be mild to severe, and may affect different organ-systems of the body.AIMS:
The main objective of this study was to determine the demographic, clinical and immunological factors associated with long COVID. MATERIALS &METHODS:
We conducted a nested case control study, with a total of 94 study participants initially included, and 64 participants matched for age and sex for biomarker analyses.RESULTS:
32/94 (34.1%) of all the participants had long COVID. Respiratory symptoms were the most common (59.5%) followed by the musculoskeletal symptoms (28.1%). HIV was an independent predictor of long COVID (adjusted odds ratio = 2.7; p = .037). In all the 64 matched cases and controls, IFN-ß was significantly higher among controls than cases. After stratifying by HIV, IL6 was significantly higher among cases than controls in the HIV- group (2.06 vs. 0.81 pg/mL; p = .02). On the other hand, IFN-ß was significantly higher among controls than cases in the HIV+ group (251 vs. 0 pg/mL; p = .01).CONCLUSION:
HIV infection is a risk factor for long COVID, and inflammatory markers associated with long COVID may be slightly different for HIV- and HIV+ individuals.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
COVID-19
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Immun Inflamm Dis
Año:
2023
Tipo del documento:
Article
País de afiliación:
Zambia