Real-Time Intraoperative Detection of Margins for Oral Cavity Squamous Cell Carcinoma.
Otolaryngol Head Neck Surg
; 169(5): 1390-1392, 2023 11.
Article
en En
| MEDLINE
| ID: mdl-37264991
ABSTRACT
Obtaining negative surgical cancer margins is the strongest predictor for the long-term survival of oral cavity squamous cell carcinoma patients. To verify that the tumor has been completely removed, surgeons rely on pathologic evaluation of frozen sections to determine surgical margins, which can be time-consuming and subjective. Herein, we detail the real-time intraoperative use of dynamic optical contrast imaging (DOCI), a novel imaging modality that rapidly distinguishes head and neck cancer from healthy adjacent tissues based on fluorescence decay information from spectral bands in the UV-VIS range. Analysis of DOCI revealed microscopic characterization sufficient for tissue type identification consistent with histology (p < .05). DOCI delivers a clinically relevant tool that may better inform and drive precision surgery, directly impacting surgical outcomes and improving overall survival for our patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Neoplasias de Cabeza y Cuello
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Otolaryngol Head Neck Surg
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos