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The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in lean and obese individuals in Cameroon.
Lenz, Benjamin; Andrew, Beng Amuam; Ritter, Manuel; Karunakaran, Indulekha; Gandjui, Narcisse Victor Tchamatchoua; Nchang, Lucy Cho; Surendar, Jayagopi; Ebob, Anita Obi Bate; Ehrens, Alexandra; Klarmann-Schulz, Ute; Ricchiuto, Arcangelo; Kuehlwein, Janina M; Fombad, Fanny Fri; Ngwa, Ambe Marius; Katcho, Tatiana Djikeussi; Hoerauf, Achim; Wanji, Samuel; Hübner, Marc P.
Afiliación
  • Lenz B; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Andrew BA; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Ritter M; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Karunakaran I; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Gandjui NVT; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Nchang LC; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Surendar J; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Ebob AOB; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Ehrens A; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Klarmann-Schulz U; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Ricchiuto A; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Kuehlwein JM; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Fombad FF; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Ngwa AM; German Center for Infection Research (DZIF), Bonn, Germany.
  • Katcho TD; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Hoerauf A; German Center for Infection Research (DZIF), Bonn, Germany.
  • Wanji S; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Hübner MP; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
PLoS One ; 18(6): e0285689, 2023.
Article en En | MEDLINE | ID: mdl-37267236
ABSTRACT

BACKGROUND:

Life-style metabolic diseases are steadily rising, not only in developed countries, but also in low- and middle-income countries, presenting a global health problem. Metabolic disorders like type 2 diabetes and cardiovascular diseases are among the ten leading causes of death defined by the WHO in 2019. Results from animal and observational human studies suggest a connection between the decline in human helminth infections and rise of life-style-associated metabolic diseases in developing regions. This trial was designed to investigate filarial infections and their impact on metabolic diseases in Cameroon. We hypothesize that the induction of regulatory immune responses during filarial infection reduces obesity-induced low-grade inflammatory immune responses and thereby improves metabolic parameters, whereas anthelmintic treatment abolishes this protective effect. METHODS/

DESIGN:

Participants infected with Mansonella perstans, Onchocerca volvulus and/or Loa loa being lean (BMI <25), overweight (BMI >25 and <30) or clinically obese (BMI ≥30) from Littoral regions of Cameroon will be evaluated for their parasitological, immunological, metabolic and biochemical profile before and after treatment of their parasitic infections. Anthropomorphic measurements and a detailed questionnaire will complement our analysis. The investigation will assess blood immune cell populations, serum adipokines and cytokines that could be influenced by the parasite infection and/or metabolic diseases. Further, parameters like blood glucose, homeostatic model assessment of insulin resistance (HOMA-IR), circulating lipids and circulating makers of liver function will be monitored. Parameters will be assessed before treatment, 12 and 18 months after treatment.

CONCLUSION:

The focus of this study is to obtain a comprehensive metabolic profile of the participants in rural areas of Cameroon and to investigate the relationship between filarial immunomodulation and metabolic diseases. This study will elucidate the effect of anti-filarial treatment on the metabolic and immunological parameters that partake in the development of insulin resistance, narrowing in on a potential protective effect of filarial infections on metabolic diseases. TRIAL REGISTRATION doi.org/10.1186/ISRCTN43845142, ISRCTN43845142 February 2020 Trial title Effects of filarial parasite infection on type 2 diabetes Issue date 27.10.22, V.1.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Loiasis / Onchocerca volvulus / Diabetes Mellitus Tipo 2 / Mansoneliasis Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Loiasis / Onchocerca volvulus / Diabetes Mellitus Tipo 2 / Mansoneliasis Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Alemania