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Comparison of tumor-agnostic and tumor-specific clinical oncology trial designs: a systematic review and meta-analysis.
Farid-Kapadia, Mufiza; Barton, Madelyn; Bider-Canfield, Zoe; Cheema, Parneet K; Gyawali, Bishal; Nightingale, Natalie M; Latifovic, Lidija; Conter, Henry J.
Afiliación
  • Farid-Kapadia M; Hoffmann-La Roche Limited, 7070 Mississauga Road, Mississauga, ON, L5N 5M8, Canada.
  • Barton M; Hoffmann-La Roche Limited, 7070 Mississauga Road, Mississauga, ON, L5N 5M8, Canada.
  • Bider-Canfield Z; Hoffmann-La Roche Limited, 7070 Mississauga Road, Mississauga, ON, L5N 5M8, Canada.
  • Cheema PK; William Osler Health System, 2100 Bovaird Drive East, Brampton, ON, L6R 3J7, Canada.
  • Gyawali B; Queens University, 15 Arch Street, Kingston, ON, K7L 3L4, Canada.
  • Nightingale NM; IQVIA Solutions Canada, 1875 Buckhorn Gate, Mississauga, ON, L4W 5P1, Canada.
  • Latifovic L; IQVIA Solutions Canada, 1875 Buckhorn Gate, Mississauga, ON, L4W 5P1, Canada.
  • Conter HJ; Hoffmann-La Roche Limited, 7070 Mississauga Road, Mississauga, ON, L5N 5M8, Canada.
Future Oncol ; 19(25): 1741-1752, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37283038
Two types of studies were sought, including studies that measured health outcomes in patients who were selected to receive medicine based on the location of their cancer (tumor), called tumor-specific studies; and studies that measured health outcomes in patients who were selected to receive cancer medicine regardless of the location of their cancer (tumor), called tumor-agnostic studies. From the studies found, only the studies that tested a specific type of cancer medicine (called tyrosine kinase inhibitors) on cancers with a specific genetic alteration (called BRAF-altered cancers) were identified. These studies were included in the analysis. The goal of the analysis was to determine if the two types of studies gave similar estimates of response rate, which is a type of trial outcome that measures whether the cancer shrinks or disappears. To do this, the results from the tumor-specific studies were combined with the results of the tumor-agnostic studies. No meaningful differences in the results from the tumor-specific studies compared with the tumor-agnostic studies were found. This suggests that tumor-specific studies do not yield very different results from tumor-agnostic studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Melanoma Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Future Oncol Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Melanoma Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Future Oncol Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido