Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy.
Nanomedicine (Lond)
; 18(9): 743-754, 2023 04.
Article
en En
| MEDLINE
| ID: mdl-37306216
ABSTRACT
Background:
Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells.Aim:
In vivo evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. Materials &methods:
PVA/BA NPs were synthesized and intravenously injected into tumor-bearing mice for BNCT.Results:
The in vitro boron uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful BNCT. In an in vivo study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically used boronophenylalanine for oral cancer in a murine model.Conclusion:
PVA/BA NPs exhibited effective therapeutic results for oral cancer treatments in BNCT.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Boca
/
Terapia por Captura de Neutrón de Boro
/
Nanopartículas
Límite:
Animals
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos