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Ultra-high b-Value DWI in predicting progression risk of locally advanced rectal cancer: a comparative study with routine DWI.
Zhang, Guangwen; Xu, Ziliang; Zheng, Jianyong; Wang, Mian; Ren, Jialiang; Wei, Xiaocheng; Huan, Yi; Zhang, Jinsong.
Afiliación
  • Zhang G; Department of Radiology, Xijing Hospital, Fourth Military Medical University, No.127, Chang Le West Road, Xi'an, Shaanxi, 710032, China.
  • Xu Z; Department of Radiology, Xijing Hospital, Fourth Military Medical University, No.127, Chang Le West Road, Xi'an, Shaanxi, 710032, China.
  • Zheng J; Department of Gastrointestinal Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
  • Wang M; Department of Gastrointestinal Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
  • Ren J; Department of Pharmaceuticals Diagnostics, GE Healthcare China, Beijing, 100176, China.
  • Wei X; Department of MR Research, GE Healthcare China, Beijing, 100176, China.
  • Huan Y; Department of Radiology, Xijing Hospital, Fourth Military Medical University, No.127, Chang Le West Road, Xi'an, Shaanxi, 710032, China.
  • Zhang J; Department of Radiology, Xijing Hospital, Fourth Military Medical University, No.127, Chang Le West Road, Xi'an, Shaanxi, 710032, China. stspine@163.com.
Cancer Imaging ; 23(1): 59, 2023 Jun 12.
Article en En | MEDLINE | ID: mdl-37308941
BACKGROUND: The prognosis prediction of locally advanced rectal cancer (LARC) was important to individualized treatment, we aimed to investigate the performance of ultra-high b-value DWI (UHBV-DWI) in progression risk prediction of LARC and compare with routine DWI. METHODS: This retrospective study collected patients with rectal cancer from 2016 to 2019. Routine DWI (b = 0, 1000 s/mm2) and UHBV-DWI (b = 0, 1700 ~ 3500 s/mm2) were processed with mono-exponential model to generate ADC and ADCuh, respectively. The performance of the ADCuh was compared with ADC in 3-year progression free survival (PFS) assessment using time-dependent ROC and Kaplan-Meier curve. Prognosis model was constructed with ADCuh, ADC and clinicopathologic factors using multivariate COX proportional hazard regression analysis. The prognosis model was assessed with time-dependent ROC, decision curve analysis (DCA) and calibration curve. RESULTS: A total of 112 patients with LARC (TNM-stage II-III) were evaluated. ADCuh performed better than ADC for 3-year PFS assessment (AUC = 0.754 and 0.586, respectively). Multivariate COX analysis showed that ADCuh and ADC were independent factors for 3-year PFS (P < 0.05). Prognostic model 3 (TNM-stage + extramural venous invasion (EMVI) + ADCuh) was superior than model 2 (TNM-stage + EMVI + ADC) and model 1 (TNM-stage + EMVI) for 3-year PFS prediction (AUC = 0.805, 0.719 and 0.688, respectively). DCA showed that model 3 had higher net benefit than model 2 and model 1. Calibration curve demonstrated better agreement of model 1 than model 2 and model 1. CONCLUSIONS: ADCuh from UHBV-DWI performed better than ADC from routine DWI in predicting prognosis of LARC. The model based on combination of ADCuh, TNM-stage and EMVI could help to indicate progression risk before treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Imagen de Difusión por Resonancia Magnética Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM / NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Imagen de Difusión por Resonancia Magnética Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM / NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido