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Refining Risk for Alzheimer's Disease Among Heterozygous APOEɛ4 Carriers.
Patel, Smita; Wei, Jun; Shi, Zhuqing; Rifkin, Andrew S; Zheng, S Lilly; Gelfman, Elizabeth; Duggan, David; Helfand, Brian T; Hulick, Peter J; Xu, Jianfeng.
Afiliación
  • Patel S; Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA.
  • Wei J; Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.
  • Shi Z; Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.
  • Rifkin AS; Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.
  • Zheng SL; Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.
  • Gelfman E; Northwestern Feinberg School of Medicine, Chicago, IL, USA.
  • Duggan D; Translational Genomics Research Institute, Part of City of Hope, Phoenix, AZ, USA.
  • Helfand BT; Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.
  • Hulick PJ; University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
  • Xu J; Neaman Center for Personalized Medicine, NorthShore University HealthSystem, Evanston, IL, USA.
J Alzheimers Dis ; 94(2): 483-489, 2023.
Article en En | MEDLINE | ID: mdl-37334598
ABSTRACT
In a large population-based cohort, we show not all heterozygous APOEɛ4 carriers are at increased risk for Alzheimer's disease (AD); a significantly higher AD proportion was only found for ɛ3/ɛ4, not ɛ2/ɛ4. Among ɛ3/ɛ4 carriers (24% in the cohort), the AD proportion differed considerably by polygenic risk score (PRS). In particular, the AD proportion was lower than the entire cohort for subjects in the bottom 20-percentile PRS and was higher than that of homozygous ɛ4 carriers for subjects at the top 5th-percentile PRS. Family history was no longer a significant predictor of AD risk after adjusting APOE and PRS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos