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Melanoma and subcutaneous adipose tissue: Role of peritumoral adipokines in disease characterization and prognosis.
Molinelli, Elisa; Ceccarelli, Gabriele; Fantone, Sonia; Di Mercurio, Eleonora; Gambini, Daisy; Maurizi, Andrea; Perugini, Jessica; Tossetta, Giovanni; Brisigotti, Valerio; De Simoni, Edoardo; Sapigni, Claudia; Rizzetto, Giulio; Campanati, Anna; Simonetti, Oriana; Marzioni, Daniela; Offidani, Annamaria.
Afiliación
  • Molinelli E; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Ceccarelli G; Department of Dermatology, Macerata Hospital, Macerata, Italy.
  • Fantone S; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy.
  • Di Mercurio E; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy.
  • Gambini D; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Maurizi A; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Perugini J; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy.
  • Tossetta G; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy.
  • Brisigotti V; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • De Simoni E; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Sapigni C; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Rizzetto G; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Campanati A; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Simonetti O; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Marzioni D; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy.
  • Offidani A; Dermatological Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
Pigment Cell Melanoma Res ; 36(5): 423-430, 2023 09.
Article en En | MEDLINE | ID: mdl-37334675
In the last decades, the concept of adipose organ has emerged, giving adipose tissue an active endocrine and immunologic function through the secretion of multiple cytokines and chemokines that seem to be implicated in the development and progression of several cancer, including cutaneous melanoma. In this pilot experimental study, we analyzed the expression in the peritumor subcutaneous adipose tissue of the most significant adipokines involved in the processes of carcinogenesis and metastasis in a population of melanoma patients and in two control groups composed of melanocytic nevi and epidermoid cysts, respectively. We correlated the results obtained with the main disease prognostic factors observing a statistically significant increase in the expression of PAI1, LEP, CXCL1, NAMPT, and TNF-α at the level of the peritumor tissue of the melanoma samples compared to the control groups and a correlation of the same with the histopathological prognostic factor of melanoma. Our preliminary study shows that the overexpression of PAI1, LEP, CXCL1, NAMPT, and TNF-α may contribute to the growth and to the local aggressiveness of cutaneous melanoma. It opens the hypothesis of a direct oncogenic role of subcutaneous adipose tissue and adipokines in the tumorigenesis of melanoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Pigment Cell Melanoma Res Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Pigment Cell Melanoma Res Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido