Glomerular filtration rate is an independent prognostic factor in patients with B-large cell lymphoma.
Medicine (Baltimore)
; 102(20): e33675, 2023 May 19.
Article
en En
| MEDLINE
| ID: mdl-37335743
ABSTRACT
Chronic kidney dysfunction is associated with increased mortality in multiple cancer types. Preliminary evidence suggests the same to be true for B-large cell lymphomas (B-LCL). To analyze the relationship of glomerular filtration rate (GFR) and outcome of B-LCL in detail we collected data on outcomes of 285 consecutive patients with newly diagnosed B-LCL treated at our institution with standard rituximab-containing regimens who did not have preexisting kidney disease or urinary tract obstruction at presentation. Median age was 59, range 18 to 87, 145 were male and 140 females. Forty-four had GFRâ
<â
60 mL/min, 123 had 60 to 90 mL/min, and 118â
>â
90 mL/min. Median follow-up of surviving patients was 49 months and estimated 3-year survival 76%. In univariate analysis age (Pâ
<â
.001), GFR (Pâ
=â
.014), stage (Pâ
<â
.001), performance status (Pâ
=â
.044), chemotherapy regimen (Pâ
<â
.01), and international prognostic index (IPI) (Pâ
<â
.001) were statistically significant prognostic factors. In multivariate analysis, age and GFR remained the only independent prognostic factors. Subtracting 1 from the IPI score of patients who had GFRâ
>â
90 mL/min and IPIâ
>â
1 resulted in a prognostic index that divides patients into 3 prognostic groups (low riskâ
=â
0-1, intermediate riskâ
=â
2-3 and high riskâ
=â
4-5) with an acceptable patient distribution frequency (38%, 39%, and 23%, respectively) and improved statistical significance and separation in comparison to IPI (5-year survival rates of 92%, 74%, and 42%, respectively). GFR is an important independent prognostic factor for B-LCL that should be taken into account in clinical decision making and data analysis and probably be incorporated in prognostic indices.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfoma no Hodgkin
/
Linfoma de Células B Grandes Difuso
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2023
Tipo del documento:
Article
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA