Utilization of Topical Ruxolitinib in Dermatology: A Review.
Skin Therapy Lett
; 28(3): 8-13, 2023 May.
Article
en En
| MEDLINE
| ID: mdl-37339609
ABSTRACT
As systemic administration of Janus kinase-inhibitors is associated with safety concerns, local alternatives, such as topical ruxolitinib, have been developed. This review summarizes utilization of topical ruxolitinib in dermatology. A literature search was performed of studies reporting topical use of ruxolitinib in dermatologic conditions. Twenty-four articles were included, representing 2618 patients. Results show improvement with topical ruxolitinib formulations in atopic dermatitis, vitiligo, psoriasis, and lichen planus. Results are conflicting in alopecia areata. Minimal bioavailability and low rates of mild-to-moderate treatment-related adverse events support a favorable safety profile and higher tolerability of topical ruxolitinib compared to oral Janus kinase-inhibitors.
Palabras clave
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Vitíligo
/
Dermatología
/
Inhibidores de las Cinasas Janus
Límite:
Humans
Idioma:
En
Revista:
Skin Therapy Lett
Asunto de la revista:
DERMATOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Canadá