Mechanistic evaluation of the inhibitory effect of four SGLT-2 inhibitors on SGLT 1 and SGLT 2 using physiologically based pharmacokinetic (PBPK) modeling approaches.

Zhang, Yu; Xie, Panpan; Li, Yamei; Chen, Zhixing; Shi, Aixin

Zhang, Yu; Xie, Panpan; Li, Yamei; Chen, Zhixing; Shi, Aixin.

Afiliación

Zhang Y; Clinical Trial Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Xie P; Clinical Trial Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Li Y; Clinical Trial Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Chen Z; Clinical Trial Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Shi A; Clinical Trial Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Front Pharmacol ; 14: 1142003, 2023.

Article en En | MEDLINE | ID: mdl-37342592

Palabras clave

SGLT2 inhibitors; inhibitory effect; physiologically-based pharmacokinetic model; sodium-glucose cotransporter 1 and 2; type 2 diabetes mellitus (T2DM)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: China

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