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Effect of a single dose of zoledronic acid on bone mineral density and trabecular bone score in Indian postmenopausal osteoporotic women with and without type 2 diabetes mellitus - A prospective cohort pilot study.
Merugu, Chandhana; Sahoo, Jayaprakash; Kamalanathan, Sadishkumar; Ramkumar, Govindarajalou; Reddy, Sagili Vijaya Bhaskar; Kar, Sitanshu Sekhar; Naik, Dukhabandhu; Roy, Ayan; Narayanan, Niya; Patel, Deepika; Suryadevara, Varun.
Afiliación
  • Merugu C; Department of Endocrinology, JIPMER, Puducherry, India.
  • Sahoo J; Department of Endocrinology, JIPMER, Puducherry, India. jppgi@yahoo.com.
  • Kamalanathan S; Department of Endocrinology, JIPMER, Puducherry, India.
  • Ramkumar G; Department of Radiodiagnosis, JIPMER, Puducherry, India.
  • Reddy SVB; Vijay Diabetes, Thyroid and Endocrine Clinic, Puducherry, India.
  • Kar SS; Department of Preventive and Social Medicine, JIPMER, Puducherry, India.
  • Naik D; Department of Endocrinology, JIPMER, Puducherry, India.
  • Roy A; Department of Endocrinology, AIIMS, Kalyani, West Bengal, India.
  • Narayanan N; Department of Endocrinology, JIPMER, Puducherry, India.
  • Patel D; Department of Endocrinology, JIPMER, Puducherry, India.
  • Suryadevara V; Department of Endocrinology, JIPMER, Puducherry, India.
Endocrine ; 82(1): 171-180, 2023 10.
Article en En | MEDLINE | ID: mdl-37368233
PURPOSE: The objectives were to study the effect of a single dose of intravenous (IV) zoledronic acid (ZA) on changes in bone mineral density (BMD) (lumbar spine (LS), hip, & distal forearm), trabecular bone score (TBS) and bone turnover markers (BTMs) in postmenopausal osteoporotic women with and without diabetes over 12 months. METHODS: Patients were divided into two groups: type 2 diabetes mellitus (T2DM) (n = 40) and non-DM (n = 40). Both groups received a single dose of 4 mg IV ZA at baseline. The BMD with TBS and BTMs (ß-CTX, sclerostin, P1NP) were measured at baseline, six months, and 12 months. RESULTS: At baseline, BMD in all three sites was similar in both groups. T2DM patients were older and had lower BTMs than non-DM patients. The mean increase in LS-BMD (gram/cm2) at 12 months in T2DM and the non-DM group was 3.6 ± 4.7% and 6.2 ± 4.7 %, respectively (P = 0.01). However, the age adjusted mean difference in LS BMD increment between two groups at one year was - 2.86 % (-5.02% to -0.69%), P = 0.01. There was a comparable change in BMD at other two sites, BTMs, and TBS in both the groups over one year follow-up. CONCLUSION: The gain in the LS-BMD was significantly lower in T2DM group compared to non-DM subjects over 12 months after a single IV infusion of 4 mg ZA. The explanation for this could be low bone turnover in diabetes subjects at baseline.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Fracturas Osteoporóticas Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Endocrine Asunto de la revista: ENDOCRINOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Fracturas Osteoporóticas Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Endocrine Asunto de la revista: ENDOCRINOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos