Your browser doesn't support javascript.
loading
Advances in Focused Ultrasound for the Treatment of Brain Tumors.
Rao, Rohan; Patel, Anjali; Hanchate, Kunal; Robinson, Eric; Edwards, Aniela; Shah, Sanjit; Higgins, Dominique; Haworth, Kevin J; Lucke-Wold, Brandon; Pomeranz Krummel, Daniel; Sengupta, Soma.
Afiliación
  • Rao R; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
  • Patel A; Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
  • Hanchate K; Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
  • Robinson E; Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
  • Edwards A; Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
  • Shah S; Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
  • Higgins D; Department of Neurosurgery, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Haworth KJ; Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, Cincinnati, OH 45267, USA.
  • Lucke-Wold B; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.
  • Pomeranz Krummel D; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45219, USA.
  • Sengupta S; Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Tomography ; 9(3): 1094-1109, 2023 05 29.
Article en En | MEDLINE | ID: mdl-37368542
ABSTRACT
Employing the full arsenal of therapeutics to treat brain tumors is limited by the relative impermeability of the blood-brain and blood-tumor barriers. In physiologic states, the blood-brain barrier serves a protective role by passively and actively excluding neurotoxic compounds; however, this functionality limits the penetrance of therapeutics into the tumor microenvironment. Focused ultrasound technology provides a method for overcoming the blood-brain and blood-tumor barriers through ultrasound frequency to transiently permeabilize or disrupt these barriers. Concomitant delivery of therapeutics has allowed for previously impermeable agents to reach the tumor microenvironment. This review details the advances in focused ultrasound in both preclinical models and clinical studies, with a focus on its safety profile. We then turn towards future directions in focused ultrasound-mediated therapies for brain tumors.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Tomography Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Tomography Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos