Regulating electron transportation by tungsten oxide nanocapacitors for enhanced radiation therapy.
J Nanobiotechnology
; 21(1): 205, 2023 Jun 29.
Article
en En
| MEDLINE
| ID: mdl-37386437
ABSTRACT
In the process of radiation therapy (RT), the cytotoxic effects of excited electrons generated from water radiolysis tend to be underestimated due to multiple biochemical factors, particularly the recombination between electrons and hydroxyl radicals (·OH). To take better advantage of radiolytic electrons, we constructed WO3 nanocapacitors that reversibly charge and discharge electrons to regulate electron transportation and utilization. During radiolysis, WO3 nanocapacitors could contain the generated electrons that block electron-·OH recombination and contribute to the yield of ·OH at a high level. These contained electrons could be discharged from WO3 nanocapacitors after radiolysis, resulting in the consumption of cytosolic NAD+ and impairment of NAD+-dependent DNA repair. Overall, this strategy of nanocapacitor-based radiosensitization improves the radiotherapeutic effects by increasing the utilization of radiolytic electrons and ·OH, warranting further validation in multiple tumour models and preclinical experiments.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Electrones
/
NAD
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Nanobiotechnology
Año:
2023
Tipo del documento:
Article
País de afiliación:
China