Can Pure Predictions of Activity Coefficients from PC-SAFT Assist Drug-Polymer Compatibility Screening?

Pavlis, Jáchym; Mathers, Alex; Fulem, Michal; Klajmon, Martin

Pavlis, Jáchym; Mathers, Alex; Fulem, Michal; Klajmon, Martin.

Afiliación

Pavlis J; Department of Physical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Mathers A; Department of Physical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Fulem M; Department of Physical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Klajmon M; Department of Physical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.

Mol Pharm ; 20(8): 3960-3974, 2023 08 07.

Article en En | MEDLINE | ID: mdl-37386723

Asunto(s)

Polímeros; Agua; Polímeros/química; Termodinámica; Agua/química; Preparaciones Farmacéuticas; Solubilidad; Composición de Medicamentos

Palabras clave

PC-SAFT; amorphous solid dispersions; compatibility; drugs; polymers; prediction; solubility

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Agua Tipo de estudio: Diagnostic_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies / Screening_studies Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: República Checa

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