Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil-induced hypothyroidism male BALB/c mice.
Endocrinol Diabetes Metab
; 6(5): e438, 2023 09.
Article
en En
| MEDLINE
| ID: mdl-37403247
ABSTRACT
INTRODUCTION:
Spermatogenesis is significantly influenced by the thyroid gland. Thyroid disorders can be caused by a variety of factors. Traditionally, Ellettaria cardamomum has been used to treat a variety of ailments. The effects of E. cardamomum extract (ECE) on spermatogenesis in hypothyroid mice were investigated in this study.METHODS:
In this study 42 male mice, weighing (25-35 g) were randomly divided in six groups control group (taking normal saline, 0.5 mL/day, by oral gavage [P.O.]), hypothyroid group (taking 0.1% propylthiouracil in drinking water for 2 weeks), hypothyroid groups treated by levothyroxine (15 mg/kg/day, P.O.) and hypothyroid groups treated by ECE (100, 200 and 400 mg/kg/day, P.O.). After the end of experiments the mice were anaesthetised and blood samples were collected for hormonal analysis.RESULTS:
The sperm count and microscopic studies of testes were done also. Our results showed that the T3 , T4 , testosterone levels and spermatogenesis in hypothyroid animals decreased and thyroid-stimulating hormone, follicle-stimulating hormone and luteinizing hormone increased compared with control group. Treatment by ECE reverse these effects in comparison with hypothyroid group.CONCLUSIONS:
According to our findings, the ECE may stimulates thyroid gland function and increases testosterone and spermatogenesis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Elettaria
/
Hipotiroidismo
Límite:
Animals
Idioma:
En
Revista:
Endocrinol Diabetes Metab
Año:
2023
Tipo del documento:
Article
País de afiliación:
Irán