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Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology.
Chen, Zhiyuan; Lin, Zexu; Obaid, Sofian N; Rytkin, Eric; George, Sharon A; Bach, Christopher; Madrid, Micah; Liu, Miya; LaPiano, Jessica; Fehr, Amy; Shi, Xinyu; Quirion, Nathaniel; Russo, Benjamin; Knight, Helen; Aduwari, Anthony; Efimov, Igor R; Lu, Luyao.
Afiliación
  • Chen Z; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Lin Z; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Obaid SN; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Rytkin E; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
  • George SA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Bach C; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Madrid M; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Liu M; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • LaPiano J; MedStar Georgetown University Hospital, Washington, DC 20037, USA.
  • Fehr A; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Shi X; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Quirion N; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Russo B; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Knight H; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Aduwari A; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Efimov IR; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Lu L; Department of Medicine (Cardiology), Northwestern University, Chicago, IL 60611, USA.
Sci Adv ; 9(27): eadi0757, 2023 07 07.
Article en En | MEDLINE | ID: mdl-37406128
ABSTRACT
Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantes Absorbibles / Cardiopatías Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantes Absorbibles / Cardiopatías Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos