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In vitro comparative study of red blood cell and VWF damage on 3D printing biomaterials under different blood-contacting conditions.
Jiang, Qiubo; Mei, Xu; Huan, Nana; Su, Wangwang; Cheng, Longhui; He, Haidong; Zhang, Liudi.
Afiliación
  • Jiang Q; Artificial Organ Laboratory, Bio-manufacturing Research Centre, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, Jiangsu, China.
  • Mei X; Artificial Organ Laboratory, Bio-manufacturing Research Centre, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, Jiangsu, China.
  • Huan N; Artificial Organ Laboratory, Bio-manufacturing Research Centre, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, Jiangsu, China.
  • Su W; Artificial Organ Laboratory, Bio-manufacturing Research Centre, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, Jiangsu, China.
  • Cheng L; Artificial Organ Laboratory, Bio-manufacturing Research Centre, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, Jiangsu, China.
  • He H; Robotics and Microsystems Center, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, Jiangsu, China.
  • Zhang L; Artificial Organ Laboratory, Bio-manufacturing Research Centre, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, Jiangsu, China.
Proc Inst Mech Eng H ; 237(8): 1029-1036, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37417741
ABSTRACT
Mechanical circulatory support devices (MCSDs) are often associated with hemocompatible complications such as hemolysis and gastrointestinal bleeding when treating patients with end-stage heart failure. Shear stress and exposure time have been identified as the two most important mechanical factors causing blood damage. However, the materials of MCSDs may also induce blood damage when contacting with blood. In this study, the red blood cell and von Willebrand Factor (VWF) damage caused by four 3D printing biomaterials were investigated, including acrylic, PCISO, Somos EvoLVe 128, and stainless steel. A roller pump circulation experimental platform and a rotor blood-shearing experimental platform were constructed to mimic static and dynamic blood-contacting conditions of materials in MCSDs, respectively. Free hemoglobin assay and VWF molecular weight analysis were performed on the experimental blood samples. It indicated that different 3D printing materials and technology could induce different levels of damage to red blood cells and VWF, with acrylic causing the least damage under both static and dynamic conditions. In addition, it was found that blood damage measured for the same material differed on the two platforms. Therefore, a combination of static and dynamic experiments should be used to comprehensively investigate the effects of blood damage caused by the material. It can provide a reference for the design and evaluation of materials in different components of MCSDs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor de von Willebrand / Corazón Auxiliar Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Proc Inst Mech Eng H Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor de von Willebrand / Corazón Auxiliar Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Proc Inst Mech Eng H Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2023 Tipo del documento: Article País de afiliación: China