Beyond gene expression: how MYC relieves transcription stress.
Trends Cancer
; 9(10): 805-816, 2023 10.
Article
en En
| MEDLINE
| ID: mdl-37422352
ABSTRACT
MYC oncoproteins are key drivers of tumorigenesis. As transcription factors, MYC proteins regulate transcription by all three nuclear polymerases and gene expression. Accumulating evidence shows that MYC proteins are also crucial for enhancing the stress resilience of transcription. MYC proteins relieve torsional stress caused by active transcription, prevent collisions between the transcription and replication machineries, resolve R-loops, and repair DNA damage by participating in a range of protein complexes and forming multimeric structures at sites of genomic instability. We review the key complexes and multimerization properties of MYC proteins that allow them to mitigate transcription-associated DNA damage, and propose that the oncogenic functions of MYC extend beyond the modulation of gene expression.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Reparación del ADN
Límite:
Humans
Idioma:
En
Revista:
Trends Cancer
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania