DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming.

Yang, Xuejiao; Wang, Xiao; Yang, Ying; Li, Zhiyang; Chen, Yunshuo; Shang, Siqi; Wang, Yueying

Yang, Xuejiao; Wang, Xiao; Yang, Ying; Li, Zhiyang; Chen, Yunshuo; Shang, Siqi; Wang, Yueying.

Afiliación

Yang X; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wang X; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Yang Y; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Li Z; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430000, Hubei, China.
Chen Y; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Shang S; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wang Y; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. yywang@shsmu.edu.cn.

J Transl Med ; 21(1): 481, 2023 07 18.

Article en En | MEDLINE | ID: mdl-37464424

Asunto(s)

ADN Metiltransferasa 3A; Leucemia Mieloide Aguda; Animales; Humanos; Ratones; Ciclinas/genética; Citocinas/metabolismo; ADN; ADN (Citosina-5-)-Metiltransferasas/genética; ADN (Citosina-5-)-Metiltransferasas/metabolismo; Leucemia Mieloide Aguda/patología; Mutación/genética; NAD/genética; NAD/metabolismo

Palabras clave

AML; DNMT3A mutation; Metabolic reprogramming; NAM-NAD metabolism; NAMPT

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / ADN Metiltransferasa 3A Límite: Animals / Humans Idioma: En Revista: J Transl Med Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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