Inflammatory cytokines in maternal serum between women with threatened miscarriage and normal pregnancy.
Int J Gynaecol Obstet
; 164(1): 255-261, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-37464913
ABSTRACT
OBJECTIVE:
To compare the levels of proinflammatory cytokines in women with threatened miscarriage and normal pregnancy.METHODS:
This study was a longitudinal study. Consenting women with normal pregnancy and those admitted on account of threatened miscarriage at an estimated gestational age of 6-10 weeks were included in the study. The proinflammatory cytokines interleukin-2 (IL-2) and interferon-γ (IFN-γ) and the anti-inflammatory cytokines IL-4 and IL-13 were measured at the diagnosis of threatened miscarriage (baseline) and in the 13th week of pregnancy. The χ2 test of association was used to examine the relationship between the pregnancy type and demographic characteristics; clinical history and gynecologic history. Student t test was used to compare the selected cytokine between women with threatened miscarriage and normal pregnancy.RESULTS:
There was a significantly higher IL-2 (P = 0.033), IFN-γ (P < 0.001), and IL-13 (P < 0.001) in women with threatened miscarriage than in women with normal pregnancy at the baseline. At the follow up, the results revealed a significantly higher IFN-γ level (P < 0.001) and IL-4 (P = 0.019) in women with threatened miscarriage than in women with normal pregnancies.CONCLUSION:
Proinflammatory cytokine profiles were associated with a higher risk of threatened miscarriage.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Citocinas
/
Amenaza de Aborto
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Infant
/
Pregnancy
Idioma:
En
Revista:
Int J Gynaecol Obstet
Año:
2024
Tipo del documento:
Article
País de afiliación:
Nigeria