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Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination.
Messina, Nicole L; Sperotto, Mariana G; Puga, Marco A M; da Silva, Patricia V; de Oliveira, Roberto D; Moore, Cecilia L; Pittet, Laure F; Jamieson, Tenaya; Dalcolmo, Margareth; Dos Santos, Glauce; Jardim, Bruno; Lacerda, Marcus V G; Curtis, Nigel; Croda, Julio.
Afiliación
  • Messina NL; Infectious Diseases Group, Infection and Immunity Theme, Murdoch Children's Research Institute, Parkville, VIC, Australia.
  • Sperotto MG; Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
  • Puga MAM; School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • da Silva PV; Oswaldo Cruz Foundation Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • de Oliveira RD; School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Moore CL; Oswaldo Cruz Foundation Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Pittet LF; School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Jamieson T; Oswaldo Cruz Foundation Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Dalcolmo M; State University of Mato Grosso do Sul, Dourados-Mato Grosso do Sul, Brazil.
  • Dos Santos G; Federal University of Grande Dourados, Dourados, Brazil.
  • Jardim B; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville, VIC, Australia.
  • Lacerda MVG; Infectious Diseases Group, Infection and Immunity Theme, Murdoch Children's Research Institute, Parkville, VIC, Australia.
  • Curtis N; Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
  • Croda J; Infectious Diseases, The Royal Children's Hospital Melbourne, Parkville, VIC, Australia.
Front Immunol ; 14: 1172851, 2023.
Article en En | MEDLINE | ID: mdl-37465688
ABSTRACT
Multiple factors, including vaccine platform and prior vaccinations, influence vaccine responses. We compared antibody responses to CoronaVac (Sinovac) and ChAdOx1-S (AstraZeneca-Oxford) vaccination in 874 healthcare workers in Brazil. As participants were randomised to BCG vaccination or placebo in the preceding 0-6 months as part of the BCG vaccination to reduce the impact of COVID-19 in healthcare workers (BRACE) trial, we also investigated the influence of recent BCG vaccination on antibody responses to these COVID-19 vaccines. Twenty-eight days after the second dose of each vaccine, ChAdOx1-S induced a stronger anti-spike IgG response than CoronaVac vaccination. Recent BCG vaccination did not impact IgG antibody responses to ChAdOx1-S or CoronaVac.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / COVID-19 Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / COVID-19 Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Australia