Placental drug transport and fetal exposure during pregnancy is determined by drug molecular size, chemistry, and conformation.

Fein, Katherine C; Arral, Mariah L; Kim, Julie S; Newby, Alexandra N; Whitehead, Kathryn A

Fein, Katherine C; Arral, Mariah L; Kim, Julie S; Newby, Alexandra N; Whitehead, Kathryn A.

Afiliación

Fein KC; Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States of America.
Arral ML; Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States of America.
Kim JS; Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States of America.
Newby AN; Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States of America.
Whitehead KA; Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States of America; Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States of America. Electronic address: kawhite@cmu.edu.

J Control Release ; 361: 29-39, 2023 09.

Article en En | MEDLINE | ID: mdl-37473809

Asunto(s)

Placenta; Calidad de Vida; Embarazo; Femenino; Ratones; Animales; Placenta/metabolismo; Transporte Biológico; Feto; Polímeros/metabolismo

Palabras clave

Drug delivery; Fetal toxicity; Macromolecules; Maternal health; Physicochemical properties; Placenta; Pregnancy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Calidad de Vida Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Animals / Pregnancy Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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