Proximity-inducing modalities: the past, present, and future.
Chem Soc Rev
; 52(16): 5485-5515, 2023 Aug 14.
Article
en En
| MEDLINE
| ID: mdl-37477631
ABSTRACT
Living systems use proximity to regulate biochemical processes. Inspired by this phenomenon, bifunctional modalities that induce proximity have been developed to redirect cellular processes. An emerging example of this class is molecules that induce ubiquitin-dependent proteasomal degradation of a protein of interest, and their initial development sparked a flurry of discovery for other bifunctional modalities. Recent advances in this area include modalities that can change protein phosphorylation, glycosylation, and acetylation states, modulate gene expression, and recruit components of the immune system. In this review, we highlight bifunctional modalities that perform functions other than degradation and have great potential to revolutionize disease treatment, while also serving as important tools in basic research to explore new aspects of biology.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Procesamiento Proteico-Postraduccional
/
Ubiquitina
Idioma:
En
Revista:
Chem Soc Rev
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos