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IMMUNOREACT 6: weak immune surveillance characterizes early-onset rectal cancer.
Spolverato, Gaya; Fassan, Matteo; Scarpa, Melania; Stepanyan, Astghik; De Simoni, Ottavia; Scognamiglio, Federico; Chiminazzo, Valentina; De Nardi, Clarissa; Tamponi, Giulia; Negro, Silvia; Angriman, Imerio; Kotsafti, Andromachi; Ruffolo, Cesare; Vignotto, Chiara; Zizzo, Maurizio; Marchegiani, Francesco; Facci, Luca; Bergamo, Francesca; Brignola, Stefano; Businello, Gianluca; Guzzardo, Vincenza; Dal Santo, Luca; Salmaso, Roberta; Ceccon, Carlotta; Massani, Marco; Pozza, Anna; Cataldo, Ivana; Stecca, Tommaso; Dei Tos, Angelo Paolo; Zagonel, Vittorina; Pilati, Pierluigi; Franzato, Boris; Scapinello, Antonio; Pirozzolo, Giovanni; Recordare, Alfonso; Merenda, Roberto; Bordignon, Giovanni; Laurino, Licia; Guerriero, Silvio; Romiti, Chiara; Portale, Giuseppe; Cipollari, Chiara; Candioli, Salvatore; Gavagna, Laura; Pozza, Giulia; Godina, Mario; Mondi, Isabella; Noaro, Giulia; Ortenzi, Monica; Guerrieri, Mario.
Afiliación
  • Spolverato G; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Fassan M; Department of Medicine DIMED, University of Padua, Padua, Italy.
  • Scarpa M; Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
  • Stepanyan A; Immunology and Molecular Oncology Diagnostics Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
  • De Simoni O; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Scognamiglio F; Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
  • Chiminazzo V; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • De Nardi C; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Tamponi G; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Negro S; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Angriman I; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Kotsafti A; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Ruffolo C; Immunology and Molecular Oncology Diagnostics Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
  • Vignotto C; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Zizzo M; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Marchegiani F; Chirurgia ad indirizzo oncologico, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Facci L; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Bergamo F; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Brignola S; Medical Oncology 1 Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
  • Businello G; UOC Anatomia e Istologia Patologica, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
  • Guzzardo V; UOC Anatomia Patologica, Azienda ULSS 5 Polesana, Rovigo, Italy.
  • Dal Santo L; Department of Medicine DIMED, University of Padua, Padua, Italy.
  • Salmaso R; UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
  • Ceccon C; Department of Medicine DIMED, University of Padua, Padua, Italy.
  • Massani M; Department of Medicine DIMED, University of Padua, Padua, Italy.
  • Pozza A; UOC Chirurgia 1, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
  • Cataldo I; UOC Chirurgia 1, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
  • Stecca T; UOC Anatomia e Istologia Patologica, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
  • Dei Tos AP; UOC Chirurgia 1, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
  • Zagonel V; Department of Medicine DIMED, University of Padua, Padua, Italy.
  • Pilati P; Medical Oncology 1 Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
  • Franzato B; Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
  • Scapinello A; Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
  • Pirozzolo G; Anatomy and Pathological Histology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
  • Recordare A; UOC Chirurgia Generale, Ospedale dell'Angelo, Azienda ULSS 3 Serenissima, Mestre Venezia, Italy.
  • Merenda R; UOC Chirurgia Generale, Ospedale dell'Angelo, Azienda ULSS 3 Serenissima, Mestre Venezia, Italy.
  • Bordignon G; UOC Chirurgia Generale, Ospedale SS. Giovanni e Paolo, Azienda ULSS 3 Serenissima, Venezia, Italy.
  • Laurino L; UOC Chirurgia Generale, Ospedale SS. Giovanni e Paolo, Azienda ULSS 3 Serenissima, Venezia, Italy.
  • Guerriero S; UOC Anatomia Patologica, Azienda ULSS 3 Serenissima, Mestre Venezia, Italy.
  • Romiti C; UOC Chirurgia Generale, Ospedale Murri di Fermo, ASUR 4, Fermo, Italy.
  • Portale G; UOC Chirurgia Generale, Ospedale Murri di Fermo, ASUR 4, Fermo, Italy.
  • Cipollari C; UOC Chirurgia Generale, Azienda ULSS 6 Euganea, Cittadella, Italy.
  • Candioli S; UOC Chirurgia Generale, Azienda ULSS 6 Euganea, Cittadella, Italy.
  • Gavagna L; UOC Chirurgia, Azienda ULSS 1 Dolomiti, Belluno, Italy.
  • Pozza G; UOC Chirurgia, Azienda ULSS 1 Dolomiti, Belluno, Italy.
  • Godina M; UOC Chirurgia Generale, Ospedale dell'Angelo, Azienda ULSS 3 Serenissima, Mestre Venezia, Italy.
  • Mondi I; UOC Chirurgia Generale, Ospedale dell'Angelo, Azienda ULSS 3 Serenissima, Mestre Venezia, Italy.
  • Noaro G; UOC Chirurgia Generale, Ospedale dell'Angelo, Azienda ULSS 3 Serenissima, Mestre Venezia, Italy.
  • Ortenzi M; UOC Chirurgia Generale, Azienda ULSS 2 Marca Trevigiana, Montebelluna, Italy.
  • Guerrieri M; SOD Clinica Chirurgica Generale e D'Urgenza, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.
Br J Surg ; 110(11): 1490-1501, 2023 Oct 10.
Article en En | MEDLINE | ID: mdl-37478362
BACKGROUND: Colon cancer in young patients is often associated with hereditary syndromes; however, in early-onset rectal cancer, mutations of these genes are rarely observed. The aim of this study was to analyse the features of the local immune microenvironment and the mutational pattern in early-onset rectal cancer. METHODS: Commonly mutated genes were analysed within a rectal cancer series from the University Hospital of Padova. Mutation frequency and immune gene expression in a cohort from The Cancer Genome Atlas ('TCGA') were compared and immune-cell infiltration levels in the healthy rectal mucosa adjacent to rectal cancers were evaluated in the IMMUNOlogical microenvironment in REctal AdenoCarcinoma Treatment 1 and 2 ('IMMUNOREACT') series. RESULTS: In the authors' series, the mutation frequency of BRAF, KRAS, and NRAS, as well as microsatellite instability frequency, were not different between early- and late-onset rectal cancer. In The Cancer Genome Atlas series, among the genes with the most considerable difference in mutation frequency between young and older patients, seven genes are involved in the immune response and CD69, CD3, and CD8ß expression was lower in early-onset rectal cancer. In the IMMUNOlogical microenvironment in REctal AdenoCarcinoma Treatment 1 and 2 series, young patients had a lower rate of CD4+ T cells, but higher T regulator infiltration in the rectal mucosa. CONCLUSION: Early-onset rectal cancer is rarely associated with common hereditary syndromes. The tumour microenvironment is characterized by a high frequency of mutations impairing the local immune surveillance mechanisms and low expression of immune editing-related genes. A constitutively low number of CD4 T cells associated with a high number of T regulators indicates an imbalance in the immune surveillance mechanisms.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Screening_studies Idioma: En Revista: Br J Surg Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Screening_studies Idioma: En Revista: Br J Surg Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido