A comprehensive assessment of redox balance in small for gestational age newborns and their mothers.
Lab Med
; 55(2): 209-214, 2024 Mar 07.
Article
en En
| MEDLINE
| ID: mdl-37499047
ABSTRACT
OBJECTIVE:
The objective of this study was to assess oxidative stress in small for gestational age (SGA) newborns and their mothers by evaluating intra- and extracellular thiol homeostasis and the quantification of major oxidants and antioxidants.METHODS:
A total of 75 mothers and their 75 newborns (43 SGA) were enrolled in this study. Thiol-disulfide homeostasis, serum myeloperoxidase, catalase, total oxidant, and antioxidant status were analyzed. Additionally, erythrocytic glutathione (GSH) homeostasis was measured.RESULTS:
Although native and total thiol levels were decreased, disulfide levels were increased in SGA groups. Additionally, myeloperoxidase activity and total oxidant status levels were significantly elevated whereas total antioxidant status levels and enzymatic antioxidant systems were diminished in SGA groups. Similarly, intra-erythrocytic GSH homeostasis was shifted in favor of oxidants in SGA groups.CONCLUSION:
Our results demonstrate that insufficient antioxidant systems in mothers and a robust source of oxidative stress in SGA might contribute to the pathophysiology of SGA births.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxidantes
/
Antioxidantes
Límite:
Humans
/
Newborn
Idioma:
En
Revista:
Lab Med
Año:
2024
Tipo del documento:
Article
País de afiliación:
Turquía