Binding profile of quinonoid-dihydrobiopterin to quinonoid-dihydropteridine reductase examined by in silico and in vitro analyses.

Kono, Haruka; Hara, Satoshi; Furuta, Tadaomi; Ichinose, Hiroshi

Kono, Haruka; Hara, Satoshi; Furuta, Tadaomi; Ichinose, Hiroshi.

Afiliación

Kono H; School of Life Science and Technology, Tokyo Institute of Technology, 4259-B7, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
Hara S; School of Life Science and Technology, Tokyo Institute of Technology, 4259-B7, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
Furuta T; School of Life Science and Technology, Tokyo Institute of Technology, 4259-B7, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
Ichinose H; School of Life Science and Technology, Tokyo Institute of Technology, 4259-B7, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.

J Biochem ; 174(5): 441-450, 2023 Oct 31.

Article en En | MEDLINE | ID: mdl-37540845

Asunto(s)

Biopterinas; Dihidropteridina Reductasa; Humanos; Dihidropteridina Reductasa/metabolismo

Palabras clave

molecular dynamics; pteridine reductase; quinonoid-dihydropteridine reductase; tetrahydrobiopterinAbbreviations: AAAH, aromatic aminoacid hydroxylase; BH2, dihydrobiopterin; BH4, tetrahydrobiopterin; DHFR, dihydrofolate reductase; NADH, nicotinamide adenine dinucleotide; NAM, nicotinamide; MD, molecular dynamics; PT, pterin; PTR1, pteridine reductase 1; qBH2; quinonoid dihydrobiopterin; qDHF, quinonoid dihydrofolate; QDPR, quinonoid dihydropteridine reductase; SDR, short-chain dehydrogenase/reductase; THF, tetrahydrofolate

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biopterinas / Dihidropteridina Reductasa Límite: Humans Idioma: En Revista: J Biochem Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

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