Meiosis in Plasmodium: how does it work?
Trends Parasitol
; 39(10): 812-821, 2023 10.
Article
en En
| MEDLINE
| ID: mdl-37541799
ABSTRACT
Meiosis is sexual cell division, a process in eukaryotes whereby haploid gametes are produced. Compared to canonical model eukaryotes, meiosis in apicomplexan parasites appears to diverge from the process with respect to the molecular mechanisms involved; the biology of Plasmodium meiosis, and its regulation by means of post-translational modification, are largely unexplored. Here, we discuss the impact of technological advances in cell biology, evolutionary bioinformatics, and genome-wide functional studies on our understanding of meiosis in the Apicomplexa. These parasites, including Plasmodium falciparum, Toxoplasma gondii, and Eimeria spp., have significant socioeconomic impact on human and animal health. Understanding this key stage during the parasite's life cycle may well reveal attractive targets for therapeutic intervention.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasmodium
/
Toxoplasma
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Parasitol
Asunto de la revista:
PARASITOLOGIA
Año:
2023
Tipo del documento:
Article