CYP2C19 loss-of-function alleles and use of omeprazole or esomeprazole increase the risk of cardiovascular outcomes in patients using clopidogrel.

Ramste, Markus; Ritvos, Markus; Häyrynen, Sergei; Kiiski, Johanna I; Niemi, Mikko; Sinisalo, Juha

Ramste, Markus; Ritvos, Markus; Häyrynen, Sergei; Kiiski, Johanna I; Niemi, Mikko; Sinisalo, Juha.

Afiliación

Ramste M; Heart and Lung Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Ritvos M; Heart and Lung Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Häyrynen S; Veracell Oy, Tampere, Finland.
Kiiski JI; Department of Clinical Pharmacology and Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Niemi M; Department of Clinical Pharmacology and Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Sinisalo J; Department of Clinical Pharmacology, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland.

Clin Transl Sci ; 16(10): 2010-2020, 2023 10.

Article en En | MEDLINE | ID: mdl-37551775

Asunto(s)

Inhibidores de Agregación Plaquetaria; Accidente Cerebrovascular; Humanos; Clopidogrel/efectos adversos; Inhibidores de Agregación Plaquetaria/efectos adversos; Alelos; Esomeprazol/efectos adversos; Omeprazol/efectos adversos; Citocromo P-450 CYP2C19/genética; Estudios Prospectivos; Genotipo; Resultado del Tratamiento

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Agregación Plaquetaria / Accidente Cerebrovascular Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Transl Sci Año: 2023 Tipo del documento: Article País de afiliación: Finlandia

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