BCR-ABL1-driven exosome-miR130b-3p-mediated gap-junction Cx43 MSC intercellular communications imply therapies of leukemic subclonal evolution.

Chai, Chengyan; Sui, Ke; Tang, Jun; Yu, Hao; Yang, Chao; Zhang, Hongyang; Li, Shengwen Calvin; Zhong, Jiang F; Wang, Zheng; Zhang, Xi

Chai, Chengyan; Sui, Ke; Tang, Jun; Yu, Hao; Yang, Chao; Zhang, Hongyang; Li, Shengwen Calvin; Zhong, Jiang F; Wang, Zheng; Zhang, Xi.

Afiliación

Chai C; Medical Center of Hematology, Second Affiliated Hospital, Army Medical University, Chongqing,400037, China.
Sui K; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400037, China.
Tang J; Jinfeng Laboratory, Chongqing, 401329, China.
Yu H; Medical Center of Hematology, Second Affiliated Hospital, Army Medical University, Chongqing,400037, China.
Yang C; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400037, China.
Zhang H; Jinfeng Laboratory, Chongqing, 401329, China.
Li SC; Medical Center of Hematology, Second Affiliated Hospital, Army Medical University, Chongqing,400037, China.
Zhong JF; Medical Center of Hematology, Second Affiliated Hospital, Army Medical University, Chongqing,400037, China.
Wang Z; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400037, China.
Zhang X; Medical Center of Hematology, Second Affiliated Hospital, Army Medical University, Chongqing,400037, China.

Theranostics ; 13(12): 3943-3963, 2023.

Article en En | MEDLINE | ID: mdl-37554265

Asunto(s)

Conexina 43; Exosomas; Leucemia Mielógena Crónica BCR-ABL Positiva; MicroARNs; Humanos; Comunicación Celular/genética; Conexina 43/metabolismo; Exosomas/metabolismo; Leucemia Mielógena Crónica BCR-ABL Positiva/tratamiento farmacológico; MicroARNs/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Microambiente Tumoral/genética; Proteínas Supresoras de Tumor/metabolismo

Palabras clave

B progenitor acute lymphoblastic leukemia; BCR-ABL1; Cx43; MSCs; acute lymphoblastic leukemia; chemotherapy resistance; gap junctions; leukemic microenvironment; miR-130a and miR-130b; stemness

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Conexina 43 / MicroARNs / Exosomas Límite: Humans Idioma: En Revista: Theranostics Año: 2023 Tipo del documento: Article País de afiliación: China

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