Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades.

Smolen, Kali A; Papke, Cinta M; Swingle, Mark R; Musiyenko, Alla; Li, Chenchen; Salter, E Alan; Camp, Ashley D; Honkanen, Richard E; Kettenbach, Arminja N

Smolen, Kali A; Papke, Cinta M; Swingle, Mark R; Musiyenko, Alla; Li, Chenchen; Salter, E Alan; Camp, Ashley D; Honkanen, Richard E; Kettenbach, Arminja N.

Afiliación

Smolen KA; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Papke CM; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama, USA.
Swingle MR; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama, USA.
Musiyenko A; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama, USA.
Li C; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama, USA.
Salter EA; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama, USA.
Camp AD; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama, USA.
Honkanen RE; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama, USA. Electronic address: rhonkanen@southalabama.edu.
Kettenbach AN; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA; Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA. Electronic address: Arminja.N.Kettenbach@dartmouth.edu.

J Biol Chem ; 299(9): 105154, 2023 09.

Article en En | MEDLINE | ID: mdl-37572851

Asunto(s)

Anomalías Múltiples; Humanos; Trastorno del Espectro Autista; Células HEK293; Diana Mecanicista del Complejo 1 de la Rapamicina/genética; Diana Mecanicista del Complejo 1 de la Rapamicina/metabolismo; Fosforilación; Proteína Fosfatasa 2/genética; Proteína Fosfatasa 2/metabolismo; Proteómica; Proteína S6 Ribosómica/genética; Proteína S6 Ribosómica/metabolismo; Anomalías Múltiples/metabolismo; Anomalías Múltiples/patología

Palabras clave

Jordan's syndrome; LY2584702; PP2A; PPP2R5D; PPP2R5D-related neurodevelopmental disorder; mTOR; phosphatase; phosphoproteomics; proteomics; rapamycin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anomalías Múltiples Límite: Humans Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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