Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake.
Nanoscale Horiz
; 8(10): 1377-1385, 2023 09 26.
Article
en En
| MEDLINE
| ID: mdl-37591816
ABSTRACT
Poly(ethylene glycol) (PEG) is the gold standard used to reduce unspecific protein adsorption and prolong nanocarrier circulation time. However, this stealth effect could be counteracted by the increasing prevalence of anti-PEG antibodies in the bloodstream. Up to now, the presence of anti-PEG antibodies in the protein corona and their effect on cell uptake has not been investigated yet. Our results showed a high concentration and prevalence of anti-PEG antibodies in the German population. PEGylated nanocarriers exhibited a higher level of anti-PEG antibodies in the protein corona compared to non-PEGylated, which lead to higher uptake in macrophages. Consequently, the anti-PEG antibodies in the protein corona could mitigate the stealth effect of PEG, leading to accelerated blood clearance and unwanted side effects.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nanopartículas
/
Corona de Proteínas
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Nanoscale Horiz
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania