Association of urinary arsenic with the oxidative DNA damage marker 8-hydroxy-2 deoxyguanosine: A meta-analysis.
Sci Total Environ
; 904: 166600, 2023 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-37659570
ABSTRACT
BACKGROUND:
The International Agency for Research on Cancer has classified arsenic as a class I carcinogen. Oxidative DNA damage is a typical early precursor to recognized malignancies. The most sensitive early independent marker of oxidative DNA damage is believed to be 8-hydroxy-2 deoxyguanosine (8-OHdG). To date, research on the link between urinary arsenic and 8-OHdG has not been consistent.OBJECTIVE:
This study was aimed at exploring the effects of urinary arsenic on 8-OHdG in human urine.METHODS:
A literature search until January 2023 was performed on the PubMed, Cochrane Library, Web of Science, Embase, and Scopus databases through a combination of computer and manual retrieval. Stata 12.0 was used to examine the degree of heterogeneity among included studies. The percentage change and 95 % confidence interval (95 % CI) of 8-OHdG were calculated between populations exposed to different doses. We used a random effect model because the degree of heterogeneity exceeded 50 %. Sensitivity analysis and testing for publication bias were performed.RESULTS:
This meta-analysis included nine studies, most of which were performed in China. After exposure to arsenic, urinary arsenic (per 10 µg/g creatinine increase) was associated with the increased 8-OHdG (% change = 41.49 %, 95 % CI 19.73 %, 63.25 %). Subgroup analysis indicated that the percentage change in 8-OHdG in urine was more pronounced in people exposed to arsenic <50 µg/L (% change = 24.60 %, 95 % CI 17.35 %, 37.85 %). In studies using total urinary arsenic content as an indicator, the percentage change in 8-OHdG in urine was more significant (% change = 60.38 %, 95 % CI 15.08 %, 105.68 %).CONCLUSION:
The 8-OHdG levels in human urine significantly increased after exposure to environmental arsenic, thus suggesting that arsenic exposure is correlated with oxidative DNA damage.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arsénico
Tipo de estudio:
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Sci Total Environ
Año:
2023
Tipo del documento:
Article
País de afiliación:
China