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Genotypic sex shapes maternal care in the African pygmy mouse, Mus minutoides.
Heitzmann, Louise D; Challe, Marie; Perez, Julie; Castell, Laia; Galibert, Evelyne; Martin, Agnès O; Valjent, Emmanuel; Veyrunes, Frédéric.
Afiliación
  • Heitzmann LD; ISEM, Institut des Sciences de l'Evolution de Montpellier, Université de Montpellier, CNRS, IRD, Montpellier, France.
  • Challe M; ISEM, Institut des Sciences de l'Evolution de Montpellier, Université de Montpellier, CNRS, IRD, Montpellier, France.
  • Perez J; ISEM, Institut des Sciences de l'Evolution de Montpellier, Université de Montpellier, CNRS, IRD, Montpellier, France.
  • Castell L; IGF, Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.
  • Galibert E; IGF, Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.
  • Martin AO; IGF, Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.
  • Valjent E; IGF, Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.
  • Veyrunes F; ISEM, Institut des Sciences de l'Evolution de Montpellier, Université de Montpellier, CNRS, IRD, Montpellier, France.
Proc Biol Sci ; 290(2006): 20231224, 2023 09 13.
Article en En | MEDLINE | ID: mdl-37670585
Sexually dimorphic behaviours, such as parental care, have long been thought to be mainly driven by gonadal hormones. In the past two decades, a few studies have challenged this view, highlighting the direct influence of the sex chromosome complement (XX versus XY or ZZ versus ZW). The African pygmy mouse, Mus minutoides, is a wild mouse species with naturally occurring XY sex reversal induced by a third, feminizing X* chromosome, leading to three female genotypes: XX, XX* and X*Y. Here, we show that sex reversal in X*Y females shapes a divergent maternal care strategy (maternal aggression, pup retrieval and nesting behaviours) from both XX and XX* females. Although neuroanatomical investigations were inconclusive, we show that the dopaminergic system in the anteroventral periventricular nucleus of the hypothalamus is worth investigating further as it may support differences in pup retrieval behaviour between females. Combining behaviours and neurobiology in a rodent subject to natural selection, we evaluate potential candidates for the neural basis of maternal behaviours and strengthen the underestimated role of the sex chromosomes in shaping sex differences in brain and behaviours. All things considered, we further highlight the emergence of a third sexual phenotype, challenging the binary view of phenotypic sexes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sexo / Caracteres Sexuales / Conducta Materna / Ratones Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Biol Sci Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sexo / Caracteres Sexuales / Conducta Materna / Ratones Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Biol Sci Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido