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COVID-19 hospitalization increases the risk of developing glioblastoma: a bidirectional Mendelian-randomization study.
Dong, Jiajun; Wang, Shengnan; Xie, Haoqun; Mou, Yanhao; Zhu, Hao; Peng, Yilong; Xi, Jianxin; Zhong, Minggu; Xie, Zhengyuan; Jiang, Zongyuan; Wang, Kang; Chen, Hongyu; Yang, Wenzhuo; Zhu, Mingqin; Wen, Yufeng; Wu, Yi.
Afiliación
  • Dong J; Department of Neurosurgery, Jiangmen Central Hospital, Jiangmen, China.
  • Wang S; Department of Neurology, The First Hospital of Jilin University, Changchun, China.
  • Xie H; Department of Neurosurgery, Cancer Hospital of Sun Yat sen University, Guangzhou, China.
  • Mou Y; Department of Neurosurgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Zhu H; Department of Hepatology, The First Hospital of Jilin University, Changchun, China.
  • Peng Y; Department of Neurosurgery, Jiangmen Central Hospital, Jiangmen, China.
  • Xi J; Clinical College, Jilin University, Changchun, China.
  • Zhong M; Department of Neurosurgery, Jiangmen Central Hospital, Jiangmen, China.
  • Xie Z; Department of Neurosurgery, Jiangmen Central Hospital, Jiangmen, China.
  • Jiang Z; Department of Neurosurgery, Jiangmen Central Hospital, Jiangmen, China.
  • Wang K; Department of Neurosurgery, Jiangmen Central Hospital, Jiangmen, China.
  • Chen H; Department of Neurosurgery, Cancer Hospital of Sun Yat sen University, Guangzhou, China.
  • Yang W; Department of Neurosurgery, Cancer Hospital of Sun Yat sen University, Guangzhou, China.
  • Zhu M; Department of Neurology, The First Hospital of Jilin University, Changchun, China.
  • Wen Y; Department of Bioengineering, University of Texas at Arlington, Arlington, TX, United States.
  • Wu Y; Department of Neurosurgery, Jiangmen Central Hospital, Jiangmen, China.
Front Oncol ; 13: 1185466, 2023.
Article en En | MEDLINE | ID: mdl-37671050
Background: As a result of the COVID-19 pandemic, patients with glioblastoma (GBM) are considered a highly vulnerable population. Despite this, the extent of the causative relationship between GBM and COVID-19 infection is uncertain. Methods: Genetic instruments for SARS-CoV-2 infection (38,984 cases and 1,644,784 control individuals), COVID-19 hospitalization (8,316 cases and 1,549,095 control individuals), and COVID-19 severity (4,792 cases and 1,054,664 control individuals) were obtained from a genome-wide association study (GWAS) from European populations. A total of 6,183 GBM cases and 18,169 controls from GWAS were enrolled in our study. Their associations were evaluated by applying Mendelian randomization (MR) including IVW meta-analysis, MR-Egger regression, and weighted-median analysis. To make the conclusions more robust and reliable, sensitivity analyses were performed. Results: Our results showed that genetically predicted COVID-19 hospitalization increases the risk of GBM (OR = 1.202, 95% CI = 1.035-1.395, p = 0.016). In addition, no increased risk of SARS-CoV-2 infection, COVID-19 hospitalization and severity were observed in patients with any type of genetically predicted GBM. Conclusion: Our MR study indicated for the first time that genetically predicted COVID-19 hospitalization was demonstrated as a risk factor for the development of GBM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza