Damaged mitochondria recruit the effector NEMO to activate NF-&#954;B signaling.

Harding, Olivia; Holzer, Elisabeth; Riley, Julia F; Martens, Sascha; Holzbaur, Erika L F

Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling.

Harding, Olivia; Holzer, Elisabeth; Riley, Julia F; Martens, Sascha; Holzbaur, Erika L F.

Afiliación

Harding O; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Holzer E; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Max Perutz Labs, Vienna Biocenter Campus, Vienna, Austria; Center for Molecular Biology, Department of Biochemistry and Cell Biology, University of Vienna, Vienna, Austria; Vienna Biocenter PhD Pro
Riley JF; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Martens S; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Max Perutz Labs, Vienna Biocenter Campus, Vienna, Austria; Center for Molecular Biology, Department of Biochemistry and Cell Biology, University of Vienna, Vienna, Austria.
Holzbaur ELF; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: holzbaur@pennmedicine.upenn.edu.

Mol Cell ; 83(17): 3188-3204.e7, 2023 09 07.

Article en En | MEDLINE | ID: mdl-37683611

Asunto(s)

FN-kappa B; Transducción de Señal; FN-kappa B/genética; Quinasa I-kappa B/genética; Proteínas Serina-Treonina Quinasas/genética; Mitocondrias/genética

Palabras clave

ALS; NEMO; NF-κB; NF-κB effector molecule; Parkin; Parkinson's disease; SQSTM1/p62; amyotrophic lateral sclerosis; cell stress; innate immunity; mitophagy; neurodegeneration; neuroinflammation; optineurin nuclear factor kappa B; phase separation; ubiquitin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / FN-kappa B Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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