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Association between Left Atrial Late Gadolinium Enhancement and Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis (MESA).
Zghaib, Tarek; Quinaglia A C Silva, Thiago; Ambale-Venkatesh, Bharath; Xie, Eric; Ostovaneh, Mohammad R; Habibi, Mohammadali; Bluemke, David A; Soliman, Elsayed Z; Wu, Colin O; Heckbert, Susan R; Nazarian, Saman; Lima, João A C.
Afiliación
  • Zghaib T; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Quinaglia A C Silva T; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Ambale-Venkatesh B; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Xie E; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Ostovaneh MR; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Habibi M; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Bluemke DA; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Soliman EZ; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Wu CO; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Heckbert SR; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Nazarian S; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
  • Lima JAC; From the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.);
Radiol Cardiothorac Imaging ; 5(4): e220047, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37693199
ABSTRACT

Purpose:

To determine the prevalence and correlates of left atrial (LA) late gadolinium enhancement (LGE) at cardiac MRI and its association with atrial fibrillation (AF) in a population-based sample from the Multi-Ethnic Study of Atherosclerosis (MESA). Materials and

Methods:

In this secondary post hoc analysis of the MESA cohort (ClinicalTrials.gov no. NCT00005487), participants without AF underwent LGE cardiac MRI at the fifth examination (2010-2012). LA LGE burden was quantified using the image intensity ratio technique on biplane long-axis two-dimensional (2D) LGE images without fat saturation. Survival analysis was performed with log-rank testing and Cox regression.

Results:

Of 1697 participants (mean age, 67 years ± 9 [SD]; 872 men), 1035 (61%) had LA LGE, and 75 (4.4%) developed AF during follow-up (median, 3.95 years). At univariable analysis, LA LGE was associated with age (ß = .010 [95% CI .005, .015], P < .001), diastolic blood pressure (ß = .005 [95% CI .001, .009], P = .02), HbA1c level (ß = .06 [95% CI .02, .11], P = .009), heart failure (ß = .60 [95% CI .11, 1.08], P = .02), LA volume (ß = .008 [95% CI .004, .012], P < .001), and LA function (emptying fraction, LA global longitudinal strain, LA early diastolic peak longitudinal strain rate, and LA late diastolic peak strain rate; all P < .05). After adjusting for the variables in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) AF score, LA LGE independently helped predict incident AF (hazard ratio = 1.46 [95% CI 1.13, 1.88], P = .003). The highest tertile (LGE > 2%) was twice as likely to develop AF.

Conclusion:

Although limited by the 2D LGE technique employed, LA LGE was associated with adverse atrial remodeling and helped predict AF in a multiethnic population-based sample.Clinical trial registration no. NCT00005487Keywords MR Imaging, Cardiac, Epidemiology Supplemental material is available for this article. © RSNA, 2023.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Radiol Cardiothorac Imaging Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Radiol Cardiothorac Imaging Año: 2023 Tipo del documento: Article