Sex Difference in Amebiasis.
Curr Top Microbiol Immunol
; 441: 209-224, 2023.
Article
en En
| MEDLINE
| ID: mdl-37695430
ABSTRACT
Infection with the protozoan parasite Entamoeba histolytica is much more likely to cause severe, focal liver damage in males than females, although the infection rate is the same in both sexes. The differences in disease susceptibility may be due to modulation of key mechanisms of the innate immune response by sex hormones. Complement-mediated mechanisms and estrogen-dependent activated natural killer T cells lead to early elimination of the parasite in females, whereas a pathological immune axis is triggered in males. Testosterone, which is generally thought to have more immunosuppressive properties on cells of the immune response, leads to overwhelming activation of monocytes and host-dependent destruction of liver tissue in males resulting in worse outcomes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Caracteres Sexuales
/
Amebiasis
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Curr Top Microbiol Immunol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania